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Pharmaceutical Purified water

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Pharmaceutical purified water plays a central role in drug production, widely used as a solvent, ingredient, and equipment cleaning agent. Its quality is directly linked to the final quality of drugs and patient safety. Purified water is an essential raw material in the pharmaceutical production process, and its quality can directly impact both drug quality and safety. Strict microbial control of purified water systems is a core requirement of Good Manufacturing Practice (GMP). Among the various microbial control methods, ultraviolet (UV) disinfection and ozone (O3) disinfection are widely used due to their respective characteristics.

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UV disinfection devices offer flexibility and can be installed at various key points in a purified water system:

UV Total Organic Carbon (TOC) Reduction Device

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Installed in the polishing unit of purified water preparation to protect subsequent units from organic contamination or to further remove residual organic matter.

UV Residual Chlorine Removal Unit

Installed after the activated carbon filter and before the reverse osmosis membrane, it removes residual chlorine from the raw water or pretreatment process to prevent oxidation and damage to the reverse osmosis membrane.

UV Ozone Decomposition Unit

After ozone disinfection, residual ozone in the water needs to be removed before the point of use. Ultraviolet light effectively catalyzes the decomposition of ozone, converting it to oxygen, preventing residual ozone from affecting subsequent processes or the final product.

Ozone Disinfection

Ozone is primarily used for microbial control in purified water storage and distribution systems, particularly for the prevention and removal of biofilms. High-concentration ozone water is regularly injected into the system and circulated for a period of time to kill microorganisms within the system (including storage tanks and pipe linings) and destroy any biofilms that have formed.

·Continuous Low-Concentration Disinfection: A low concentration of ozone (e.g., tens of ppb) is maintained in the purified water storage tanks and distribution system to continuously inhibit microbial growth and biofilm formation.

Ozone disinfection has a strong inactivating effect on bacteria, bacterial spores, viruses, and fungi. Ozone has a certain solubility in water, and as a gas, it can theoretically diffuse into every corner of a water system, including areas difficult to reach with traditional liquid disinfectants, such as tank headspaces and valve blind spots. This allows ozone to achieve a more comprehensive range of effects when used for system-wide disinfection, compared to ultraviolet light, which is only effective on the water flow.

In pharmaceutical purified water systems, a single disinfection technology often cannot perfectly address all challenges. Ultraviolet (UV) and ozone (O3) each have unique advantages and limitations. Combining them to form a synergistic strategy is a common and effective method in the industry to improve microbial control and optimize system performance.

This combined approach uses ozone as the primary system disinfectant and UV for ozone removal and terminal protection.

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EX-UPW-TOC UV TOC System

The EX-UPW-TOC product series is an advanced and reliable system for total organic carbon (TOC) degradation in ultrapure water (UPW) production. Through enhanced 185nm transmittance, real-time UV intensity monitoring, and local/remote intelligent control, it achieves efficient, safe, and controllable TOC degradation. This equipment can reduce TOC levels in ultrapure water to below 1 ppb during the UPW production process.

EX-L UV Sterilizer

The ONYX-EX-L series features a pipeline-type design with inlet and outlet flange connections. Made of high-strength, corrosion-resistant 304/316L stainless steel, it boasts a fully enclosed and compact design.

The ONYX-EX-L incorporates innovative technologies, including food-grade processing, automatic mechanical cleaning, and CFD flow simulation, to reduce costs and significantly simplify operation and maintenance.

The ballast, operating indicator, timer, alarm, and intelligent control system are all housed within the control box. The lamps offer strong sterilization capabilities, long life, and stable operation. Their sterilization efficiency is ≥99.9%, and their lamp life is ≥12,000 hours.

OneUV UV Sterilizer

The ONYX-ONEUV series features a hygienic design, quick-connect clamps, and is constructed from high-strength, corrosion-resistant 304/316L stainless steel. Internal and external surfaces are polished to a Ra < 0.4μm, and all seals in contact with liquids are food-grade.

The ONYX-ONEUV incorporates innovative technologies, including integrated design, food-grade processing, quick-connect clamps, and CFD flow simulation, to reduce costs and significantly simplify operation and maintenance.

COG Ceramic Plate CD Ozone Generator

The COG series ozone generators feature a built-in ModuOzone? high-concentration ozone discharge chamber and a dedicated high-frequency digital power control drive system. The discharge chamber utilizes high-purity alumina ceramic, features ultra-fine-gap high-frequency discharge, and features efficient water or air cooling to ensure optimal ozone output concentration and efficiency. The equipment integrates a maintenance-free, high-efficiency air compressor and a high-purity oxygen production system, making it suitable for a variety of applications. The COG series ozone generators feature an integrated pressure regulating valve, flow meter, and LCD touchscreen, allowing for adjustable ozone concentration and output levels. The equipment boasts a compact structure, simple operation, easy installation, and ease of maintenance, making it suitable for a wide range of applications, including water treatment, deodorization, decolorization, pharmaceutical manufacturing, wastewater treatment, and food processing.

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Commercial Secondary water supply Pool & Aquarium High-quality drinking water POE/POU Aquaculture Cooling Circulating water Laboratory applications

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Resource Recycling waste plastics Construction waste Renovation waste

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Commercial EX-L UV Sterilizer EX-U UV Sterilizer ZL UV Disinfection System CLEAR Medium pressure UV Disinfection System OneUV UV Sterilizer Extrem Medium pressure UV Disinfection System UV-AOP Advanced Oxidation MOS Ceramic Plate CD Ozone Generator COG Ceramic Plate CD Ozone Generator

Photochemistry UV-Fenton Medium-pressure UV-Oxidation UV Photolysis Pasteurization UV Alternatives UV Photocatalysis Low Pressure UV-Oxidation

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Others SATBR Integrated Wastewater Treatment System D.FITE Cloth Filter Modular Wastewater Treatment System ModuOzone Ceramic Plate CD Ozone Generator

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Technical Support Process Support Product Training Research & Development Small Test Pilotscale experiment Online dose monitoring UV dose design

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Spare parts Low Pressure lamps Low Pressure Amalgam Lamps Medium Pressure Mercury Lamp VUV Low-pressure Mercury Lamp（185nm） Quartz sleeve Ballasts UV Intensity Sensor UV transmittance tester Sealing accessories Other Spare parts replacement

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